Is Vitamin A the “On/Off” Switch for Sperm Production?

In this FAMM Research Series episode, Lisa explores groundbreaking research on the role of retinoic acid—the active form of vitamin A—in spermatogenesis, testosterone production, and overall male fertility. Discover why vitamin A may act as the biological “on/off” switch for sperm production, and how nutrient-dense foods like liver could play a pivotal role in male preconception care.

Timestamps

00:00 – Introduction to the FAMM Research Series and sperm health
02:45 – Study overview: retinoic acid’s role in spermatogenesis
06:20 – How vitamin A (retinol) is stored, converted, and activated
13:15 – Retinoic acid as a regulator of sperm production pulses
17:00 – Deficiency, supplementation, and fertility applications
21:30 – Nutritional strategies: liver, cod liver oil, and sperm health
25:40 – Related research on organ meat and sperm parameters
29:15 – Retinoic acid in cryptorchidism, varicocele, and low sperm count
35:10 – WHO sperm parameters and male factor infertility

Key Takeaways

Vitamin A is essential for sperm production and may act as the “on/off switch” for spermatogenesis.
Retinoic acid pulses help regulate daily sperm production cycles in men.
Profound vitamin A deficiency is associated with reduced testosterone, testicular shrinkage, and halted sperm production.
Organ meats like liver are rich in preformed vitamin A (retinol) and may significantly enhance sperm parameters.
Targeted retinoic acid supplementation is being explored as a potential male contraceptive or fertility-enhancing treatment.

Resources and Mentions

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Disclaimer

This podcast episode is provided for educational purposes only and is not intended as medical advice. Always consult a qualified healthcare professional with questions regarding your health or treatment.